COMPOSITION USING GUANIDINE COMPOUND FOR SUPPRESSING TRANSFORMING GROWTH FACTOR (TGF)-beta

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United States of America Patent

APP PUB NO 20170246129A1
SERIAL NO

15054450

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Abstract

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The present invention relates to a composition as a transforming growth factor (TGF)-β suppressor which comprises an effective amount of guanidine compound or a pharmaceutically acceptable salt. More particularly, the present invention relates to a composition comprising a guanidine compound or a pharmaceutically acceptable salt thereof as a TGF-β suppressor, wherein the composition is characterized by suppression or reduction of TGF-β activity which is a cause of disease. The present invention relates to a method of treating various TGF-β associated diseases, the method comprising administering to the subject a composition comprising a guanidine compound or a pharmaceutically acceptable salt thereof as a TGF-β suppressor which can prevent or treat TGF-β associated diseases by suppressing or reducing TGF-β activity.

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Patent Owner(s)

Patent OwnerAddress
INSTITUTE OF CHEMISTRY CHINESE ACADEMY OF SCIENCES100190 NO 2 NORTH FIRST STREET HAIDIAN DISTRICT BEIJING ZHONGGUANCUN BEIJING CITY BEIJING CITY 100190
INSTITUTE OF HIGH ENERGY PHYSICS CHINESE ACADEMY OF SCIENCESBUILDING 101 MATERIAL BUILDING B NO 19 YUQUAN ROAD SHIJINGSHAN DISTRICT BEIJING 100049 BEIJING CITY BEIJING CITY 100049
PEKING UNIVERSITY THIRD HOSPITALULTRASOUND DIAGNOSTIC DEPARTMENT NO 49 HUAYUAN NORTH ROAD HAIDIAN DISTRICT BEIJING 100191

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
FANG, Xiaohong Beijing, CN 3 2
LI, Jingyuan Beijing, CN 14 18
LU, Zhizhen Beijing, CN 1 0
XIAO, Han Beijing, CN 53 194
XU, Zhonghe Beijing, CN 1 0
ZHANG, Mingliang Beijing, CN 17 89
ZHANG, Youyi Beijing, CN 3 8

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