COMPOSITION USING GUANIDINE COMPOUND FOR SUPPRESSING TRANSFORMING GROWTH FACTOR (TGF)-beta

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United States of America Patent

APP PUB NO 20170246129A1
SERIAL NO

15054450

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Abstract

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The present invention relates to a composition as a transforming growth factor (TGF)-β suppressor which comprises an effective amount of guanidine compound or a pharmaceutically acceptable salt. More particularly, the present invention relates to a composition comprising a guanidine compound or a pharmaceutically acceptable salt thereof as a TGF-β suppressor, wherein the composition is characterized by suppression or reduction of TGF-β activity which is a cause of disease. The present invention relates to a method of treating various TGF-β associated diseases, the method comprising administering to the subject a composition comprising a guanidine compound or a pharmaceutically acceptable salt thereof as a TGF-β suppressor which can prevent or treat TGF-β associated diseases by suppressing or reducing TGF-β activity.

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Patent Owner(s)

Patent OwnerAddress
INSTITUTE OF CHEMISTRY CHINESE ACADEMY OF SCIENCES100190 NO 2 NORTH FIRST STREET HAIDIAN DISTRICT BEIJING ZHONGGUANCUN BEIJING CITY BEIJING CITY 100190
INSTITUTE OF HIGH ENERGY PHYSICS CHINESE ACADEMY OF SCIENCES100049 SHIJINGSHAN DISTRICT YUQUANLU ROAD BEIJING NO 19 (B) BEIJING CITY BEIJING CITY 100049
PEKING UNIVERSITY THIRD HOSPITAL100191 NO 49 GARDEN NORTH ROAD BEIJING HAIDIAN DISTRICT MUNICIPAL DISTRICT BEIJING CITY 100191

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
FANG, Xiaohong Beijing, CN 3 2
LI, Jingyuan Beijing, CN 14 18
LU, Zhizhen Beijing, CN 1 0
XIAO, Han Beijing, CN 53 194
XU, Zhonghe Beijing, CN 1 0
ZHANG, Mingliang Beijing, CN 17 89
ZHANG, Youyi Beijing, CN 3 8

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