Octahydrocyclopentapyrroles, their preparation and use

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United States of America Patent

PATENT NO 9926271
SERIAL NO

15457821

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides Octahydrocyclopentapyrrole compounds having the structure: (structurally represented) wherein psi is absent or present, and when present is a bond; R1, R2, R3, R4, and R5 are each independently H, halogen, CF, or C1-C4 alkyl; R6 is absent or present, and when present is H, OH, or halogen; A is absent or present, and when present is C(O) or C(O)NH; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is C(O); and when psi is present, then R6 is absent and when psi is absent, then R6 is present, or a pharmaceutically acceptable salt thereof, for treatment of diseases characterized by excessive lipofuscin accumulation in the retina.

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Patent Owner(s)

  • COLUMBIA UNIVERSITY/THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Ping Albany, US 510 5244
Cioffi, Christopher Albany, US 28 474
Conlon, Michael Albany, US 26 305
Dobri, Nicoleta New York, US 10 175
Freeman, Emily Albany, US 20 266
Johnson, Graham Sanbornton, US 110 1135
Petrukhin, Konstantin New Windsor, US 35 467
Zhu, Lei Albany, US 347 2161

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