Iron chelators and use thereof for reducing transplant failure during rejection episodes

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United States of America Patent

PATENT NO 9763899
SERIAL NO

14653245

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Abstract

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Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. is topically applied to the surface of tissues during episodes of graft rejection.

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Patent Owner(s)

  • THE JOHNS HOPKINS UNIVERSITY;THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gurtner, Geoffrey C Woodside, US 80 1333
Jiang, Xinguo Palo Alto, US 5 3
Nicolls, Mark R Palo Alto, US 8 21
Rajadas, Jayakumar Cupertino, US 56 308
Semenza, Gregg L Reisertown, US 13 116

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