Method for detecting and purifying pancreatic beta cells

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United States of America Patent

PATENT NO 10024854
SERIAL NO

15457973

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention is based, in part, on the discovery that a polypeptide, referred to herein as Betacam, is selectively expressed on the surface of pancreatic islet cells. Thus, in one aspect, the invention is directed to compositions comprising Betacam or that can be used to detect Betacam. In another aspect, the invention provides methods of detecting (e.g., non-invasively) pancreatic beta cells from a mammalian cell source. Another aspect of the invention is directed to cellular purification of pancreatic beta cells from a heterogeneous cell source of multiple kinds. In another aspect, the invention provides methods of identifying agents that modulate activity of Betacam. In yet another aspect, the invention provides for improved treatment and diagnosis of diabetes.

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Patent Owner(s)

  • THE CLEVELAND CLINIC FOUNDATION; THE REGENT OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Davidson, Howard Denver, US 15 111
Hutton, John Aurora, US 150 2318
Jensen, Jan Shaker Heights, US 22 450
Qu, Xiaoling Beachwood, US 4 7

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