POLYMER-DRUG CONJUGATE BASED ON A POLYISOOLEFIN-BASED COPOLYMER
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United States of America Patent
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Sep 14, 2017
app pub date -
Dec 1, 2015
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Dec 1, 2014
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Abstract
A polymer-drug conjugate, which can be used in medical applications such as stents, has at least one active agent conjugated through a carboxylic acid moiety to a copolymer derived from at least one isoolefin monomer and at least one copolymerizable monomer, where the copolymerizable monomer is at least one multiolefin monomer, a β-pinene monomer or a mixture thereof. Such conjugates show improved adhesion to stainless steel and a substantial decrease in burst release of paclitaxel form a drug eluting stent (DES).
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