Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
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United States of America Patent
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Apr 14, 2020
Grant Date -
Sep 21, 2017
app pub date -
Jun 2, 2017
filing date -
Dec 20, 2002
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Abstract
Methods of identifying whether a biologically active agent affects an oncogene addicted pathway within a cancer cell, by introducing a biologically active agent suspected of affecting an oncogene addicted pathway to a first well and a negative control to a second well, and introducing a stimulating agent that stimulates the oncogene addicted pathway to both wells; monitoring cell-substrate impedance of the two wells and optionally determining cell indices from impedance values; generating an impedance based curve for each of the two wells from the impedance values or from the cell indices; comparing the impedance-based curves to determine a degree of similarity; and if significantly different concluding the biologically active agent affects the oncogene addicted pathway within the cancer cells.
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