Nucleic acids, vectors, host cells, and methods for recombinantly producing water-soluble membrane proteins

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United States of America Patent

PATENT NO 10961286
APP PUB NO 20170275343A1
SERIAL NO

15504086

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Abstract

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The present invention relates to a nucleic acid construct having a chimeric nucleic acid molecule comprising a first nucleic acid moiety encoding an amphipathic shield domain protein; a second nucleic acid moiety encoding an integral membrane protein; and a third nucleic acid moiety encoding a water soluble expression decoy protein, as well as a chimeric nucleic acid molecule having a first nucleic acid moiety encoding an amphipathic shield domain protein and a second nucleic acid moiety encoding an integral membrane protein. The present invention further relates to an expression vector, a host cell, and a protein encoded by the nucleic acid construct. Also disclosed is a method of recombinantly producing an integral membrane protein in soluble form.

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Patent Owner(s)

  • CORNELL UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Delisa, Matthew Ithaca, US 20 159
Mizrachi, Dario Ithaca, US 2 0

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