METHODS FOR THE DETECTION OF CYANIDE BASED ON DISPLACEMENT OF THE GLUTATHIONE LIGAND OF GLUTATHIONYLCOBALAMIN BY CYANIDE
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United States of America Patent
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Oct 5, 2017
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Aug 29, 2016
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Mar 29, 2016
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Abstract
Provided is a method for the detection of cyanide based on displacement of the glutathione ligand of glutathionylcobalamin by cyanide. The composition for detecting cyanide (CN−) including glutathionylcobalamin (GSCbl) and a buffer has specificity in which GSCbl does not react with other anions by nucleophilic substitution, but selectively reacts with only CN− by displacement. Further, the GSH bound to the Cbl reacts with CN− by nucleophilic substitution with high efficiency to enhance sensitivity, and cyanocobalamin (CNCbl), di-cyanocobalamin (diCNCbl) and glutathione (GSH) which are byproducts generated by nucleophilic substitution reaction of CN− may be qualitatively/quantitatively detected through spectrophotometric, naked eye, and fluorometric assays, respectively.
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