Immunohistochemistry scoring methods and compositions

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 10718773
APP PUB NO 20170285029A1
SERIAL NO

15423435

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Aspects of the present disclosure provide methods for determining the eligibility of a subject having a malignancy for treatment with an anti-PD therapeutic agent. In certain embodiments, the method includes determining, by immunohistochemistry, the number of PD-L1 positive malignant cells in a tumor tissue section as well as the number of infiltrating non-malignant cells and/or non-malignant cells of the stromal interface area. The infiltrating non-malignant cells and/or non-malignant cells of the stromal interface area are positive for a marker selected from PD-L1, CD8, CD68, and any combination thereof. Compositions and kits or performing the disclosed methods are also provided.

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Patent Owner(s)

Patent OwnerAddress
AGILENT TECHNOLOGIES INC5301 STEVENS CREEK BOULEVARD MS 1A-PB SANTA CLARA CA 95051-7201

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hanks, Debra Carpinteria, US 1 1
Hutson, Che Los Angeles, US 1 1
Nguyen, Mai Ventura, US 30 529
Srdanov, Marko Santa Barbara, US 1 1

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