Mass spectrometry for determining if a mutated variant of a target protein is present in a sample

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United States of America Patent

PATENT NO 11402385
APP PUB NO 20170292960A1
SERIAL NO

15516083

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Abstract

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A method of mass spectrometry determines if a mutated variant of a target protein is present in a sample. The method includes subjecting the sample to fragmentation so as to cause the target protein to fragment to form second generation fragment ions, and then mass analysing these fragment ions to obtain spectral data. The method determines if a mutated variant is present in the sample by determining that an ion in the spectral data has a mass to charge ratio that differs from the mass to charge ratio of an ion that would be observed if the target protein was a normal unmutated version of the target protein, and by an amount that corresponds to a mass difference that would be caused by the target protein being a mutated variant of the target protein.

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Patent Owner(s)

  • MICROMASS UK LIMITED

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brown, Jeffery Mark Hyde, GB 91 688
Green, Brian Sale, GB 48 697
Morris, Michael Raymond Glossop, GB 33 224
Williams, Jonathan West Glamorgan, GB 51 661

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