System and method for multiplexed affinity purification of proteins and cells
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United States of America Patent
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Mar 12, 2019
Grant Date -
Oct 26, 2017
app pub date -
Oct 23, 2015
filing date -
Oct 24, 2014
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Abstract
In accordance with an embodiment of the invention, there is provided a method for: a) high-throughput, multiplexed, affinity-based separation of proteins—especially low abundance proteins—from complex biological mixtures such as serum; and b) high-throughput, multiplexed, affinity-based separation of cells—especially rare cells—from complex biological mixtures such as blood or blood fractions. The separation of proteins or cells is achieved based on differential binding to affinity-capture beads of different sizes and then sorting the protein-bound or cell-bound beads using the concept of centrifugal-induced Dean migration in a spiral microfluidic device. This method enables continuous-flow, high throughput affinity-separation of milligram-scale protein samples or millions of cells in minutes after binding. This is particularly applicable to the isolation of antigen-specific antibodies from polyclonal sera and antigen-specific immune cells or circulating tumor cells from blood, both of which are otherwise highly labor-intensive and expensive to perform.
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- 15 United States
- 10 France
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Patent Owner(s)
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY; THE MASSACHUSETTS GENERAL HOSPITAL
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Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Alter, Galit | Winchester, US | 8 | 2 |
Han, Jongyoon | Bedford, US | 51 | 530 |
Hou, Han Wei | Singapore, SG | 7 | 58 |
Sarkar, Aniruddh | Cambridge, US | 3 | 1 |
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