Real time electronic cell sensing systems and applications for cell-based assays
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United States of America Patent
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Jun 23, 2020
Grant Date -
Nov 2, 2017
app pub date -
Apr 13, 2017
filing date -
Dec 20, 2002
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Abstract
Methods for identifying compounds that modulate cellular responses stimulated by IgE, which include providing an impedance-based system that monitors cell-substrate impedance of cells on a substrate; introducing cells to the substrate of the system; adding at least one test compound and IgE to the cells, wherein the at least one test compound is suspected of modulating cell responses stimulated by the IgE; adding an antigen to the cells; monitoring the cell-substrate impedance of cells on the substrate; and analyzing the cell-substrate impedance to evaluate whether the at least one test compound alters a cellular response to stimulation with the IgE.
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