Decoy oligonucleotides for the treatment of diseases

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United States of America Patent

PATENT NO 10781445
APP PUB NO 20170327825A1
SERIAL NO

15528769

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Abstract

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An isolated oligonucleotide comprising ribonucleotides is disclosed. The oligonucleotide comprises a nucleic acid sequence which encodes at least one copy of a splicing-factor binding site. The oligonucleotide is no more than 150 bases and may be devoid of a sequence that allows hybridization thereof to cellular RNA under physiological conditions. The oligonucleotide inhibits overall cellular splicing activity of a specific splicing factor. Pharmaceutical compositions comprising the oligonucleotide and uses thereof are further disclosed.

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Patent Owner(s)

  • YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Karni, Rotem Mevasseret Zion, IL 4 1

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