MATERIAL WITH HIGH OXYGEN PERMEABILITY BASED ON MARINE BIOLOGICAL SUBSTANCE, PREPARATION METHOD AND USE THEREOF
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United States of America Patent
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May 29, 2015
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Dec 12, 2014
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Abstract
A material with high oxygen permeability based on marine biological substance is disclosed. The material is obtained by compounding a silicon-containing substance with a silicon-oxy group and a bioactive substance selected from one or more of alginic acid, collagen, hyaluronic acid and a salt thereof, in the presence of a crosslinking agent. Also disclosed is a preparation method for the material including: mixing the silicon-containing substance and bioactive substance under acidic condition, and then crosslinking the mixture in the presence of a crosslinking agent. Also disclosed is a use of the material with high oxygen permeability or method thereof to prepare a corneal contact lens, corneal scaffold material, or corneal substitute. The material can satisfy the requirement of high oxygen permeability for extended wear and shows good wearing comfort. The material is biocompatible and has high safety performance.
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