Mass production and size control of nanoparticles through controlled microvortices
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United States of America Patent
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Dec 15, 2020
Grant Date -
Nov 23, 2017
app pub date -
Jun 8, 2017
filing date -
Jun 19, 2012
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Abstract
Methods for making particles, such as nanoparticles, devices useful in the methods, and particles made by the method are described herein. The methods involves the use of microfluidic device, such that upon mixing solutions of the materials to form the particles (or a solution of the material or materials to form the particles and a non-solvent for the material or materials) at least two symmetrical microvortices are formed simultaneously. The method can be used to prepare polymeric or non-polymeric particles and hybrid particles, such as lipid-polymer hybrid particles, as well as such particles containing one or more agents associated with the particles.
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