Compounds and methods for activating the apoptotic arm of the unfolded protein response

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United States of America Patent

PATENT NO 10787439
APP PUB NO 20170334889A1
SERIAL NO

15672574

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Abstract

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N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.

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Patent Owner(s)

  • THE UNIVERSITY OF KANSAS; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; BOARD OF GOVERNERS OF WAYNE STATE UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aube, Jeffrey Lawrence, US 27 59
Chung, Thomas D Y Carlsbad, US 7 183
Flaherty, Daniel P Overland Park, US 12 5
Fribley, Andrew M Brighton, US 2 0
Golden, Jennifer E Olathe, US 14 66
Hedrick, Michael Pablo Carlsbad, US 2 0
Kaufman, Randal J San Diego, US 47 1313
Pinkerton, Anthony B San Diego, US 50 229

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