LONG-ACTING POLYMERIC DELIVERY SYSTEMS COMPRISING OLANZAPINE AND A 5-HT3 RECEPTOR ANTAGONIST

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United States of America Patent

SERIAL NO

15604435

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Abstract

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Compositions comprised of olanzapine and a 5-HT3 receptor antagonist and a polyorthoester polymer are provided to provide extended release of the active agents. Also described are compositions comprising olanzapine and a polyorthoester. The compositions are effective for the prophylactic treatment or treatment of subjects at risk of or suffering from nausea and/or vomiting. The compositions are particularly useful for the prevention or treatment of acute, delayed, breakthrough or refractory chemotherapy induced nausea and vomiting (CINV). The CINV may result from, e.g., highly or moderately emetogenic cancer chemotherapy. The compositions are suitable for delivery via, e.g., intramuscular injection, intradermal injection, and subcutaneous injection.

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Patent Owner(s)

Patent OwnerAddress
HERON THERAPEUTICS INC4242 CAMPUS POINT COURT SUITE 200 SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Girotti, Lee Ann Lynn San Bruno, US 21 134
Ottoboni, Thomas B Belmont, US 81 1123

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