Detecting hematological disorders using cell-free DNA in blood

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United States of America Patent

PATENT NO 10781490
APP PUB NO 20170349948A1
SERIAL NO

15608863

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Abstract

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Techniques are provided for detecting hematological disorders using cell-free DNA in a blood sample, e.g., using plasma or serum. For example, an assay can target one or more differentially-methylated regions specific to a particular hematological cell lineage (e.g., erythroblasts). A methylation level can be quantified from the assay to determine an amount of methylated or unmethylated DNA fragments in a cell-free mixture of the blood sample. The methylation level can be compared to one or more cutoff values, e.g., that correspond to a normal range for the particular hematological cell lineage as part of determining a level of a hematological disorder.

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Patent Owner(s)

  • THE CHINESE UNIVERSITY OF HONG KONG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chan, Kwan Chee Shatin, CN 128 2844
Chiu, Rossa Wai Kwun Shatin, CN 126 3643
Lo, Yuk-Ming Dennis Homantin, CN 124 3238
Sun, Kun Shatin, CN 31 175

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