High-throughput screening of functional antibody fragments, immunoconjugate comprising the same, and adaptor-drug conjugate for screening

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United States of America Patent

PATENT NO 10752673
APP PUB NO 20170355750A1
SERIAL NO

15619835

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Abstract

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Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.

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ACADEMIA SINICANANKANG TAIPEI 115

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Hong-Sen Taipei, TW 12 22
Chiu, Yi-Kai Taipei, TW 6 2
Chuang, Shih-Hsien New Taipei, TW 23 38
Hou, Shin-Chen Taipei, TW 5 2
Hsu, Hung-Ju Taipei, TW 8 3
Kuo, Wei-Ying Taipei, TW 8 92
Lee, Chao-Pin New Taipei, TW 4 0
Tsou, Yueh-Liang Taipei, TW 5 1
Wang, Hwei-Jiung Taipei, TW 8 4
Yang, An-Suei Emeryville, US 20 38
Yu, Chung-Ming Taipei, TW 19 6

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