Methods for production of functional beta cells

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United States of America Patent

PATENT NO 10633635
APP PUB NO 20170362572A1
SERIAL NO

15622931

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Abstract

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The invention provides for methods of differentiating pancreatic endocrine cells into pancreatic beta cells expressing PDX1, NKX6.1, MAFA, UCN3 and SLC2A. These pancreatic beta cells may be obtained by step-wise differentiation of pluripotent stem cells. The pancreatic beta cells exhibit glucose-dependent mitochondrial respiration and glucose-stimulated insulin secretion similar to islet cells.

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Patent Owner(s)

Patent OwnerAddress
JANSSEN BIOTECH INC800/850 RIDGEVIEW DRIVE HORSHAM PA 19044

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Rezania, Alireza San Diego, US 110 10746
Rieck, Sebastian San Diego, US 9 8

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