Bi-functional allosteric protein-drug molecules for targeted therapy

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United States of America Patent

PATENT NO 10898582
APP PUB NO 20170368196A1
SERIAL NO

15534948

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Abstract

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Disclosed herein, is a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains, and one or more therapeutic agents, wherein the therapeutic agent is allosterically bound to the biological binding domain. Also described herein, are methods of incorporating a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains that captures the therapeutic agent without the formation of a chemical bond, and one or more therapeutic agents; physiologically acceptable compositions including them; and methods of administering the bi-functional allosteric protein-drug molecule to patients for the treatment of cancer.

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Patent Owner(s)

  • THE UNIVERSITY OF UTAH RESEARCH FOUNDATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bull, David A Salt Lake City, US 20 75
Lim, Kwangsuk Seoul, KR 2 1
Won, Youngwook Salt Lake City, US 4 1

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