Mutated factor X polypeptides and uses thereof for the treatment of haemophilia

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United States of America Patent

PATENT NO 10676730
APP PUB NO 20170369861A1
SERIAL NO

15542218

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Abstract

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The present invention relates to mutated factor (FX) polypeptides and uses thereof for the treatment of haemophilia. In particular, the present invention relates to a mutated factor X (FX) polypeptide wherein the heavy chain comprises at least one mutation selected from the group consisting of: —the mutation which consists of the substitution of the glutamic acid residue (E) at position 255 of Seq. ID No. 1 by a glutamine residue (Q), an asparagine residue (N), a serine residue (S), an alanine residue (A), or a tyrosine residue (Y); —the mutation which consists of the substitution of the glutamic acid residue (E) at position 256 of Seq. ID No. 1 by a glutamine residue (Q); and —the mutation which consists of the substitution of the glutamic acid residue (E) at position 258 of Seq. ID No. 1 by a glutamine residue (Q).

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Patent Owner(s)

Patent OwnerAddress
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)75013 PARIS
UNIVERSITE PARIS-SUD91400 ORSAY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Christophe, Olivier Le Kremlin-Bicetre, FR 15 16
Denis, Cécile Le Kremlin-Bicetre, FR 7 0
Lenting, Petrus Le Kremlin-Bicetre, FR 8 5

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