Cytotoxic benzodiazepine derivatives

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United States of America Patent

PATENT NO 10179818
APP PUB NO 20180002440A1
SERIAL NO

15645597

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.

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Patent Owner(s)

  • IMMUNOGEN INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chari, Ravi V J Newton, US 102 3831
Fishkin, Nathan Elliott Weymouth, US 20 264
Li, Wei Acton, US 2027 12714
Miller, Michael Louis Framingham, US 58 751

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