Gene editing through microfluidic delivery

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United States of America Patent

PATENT NO 11125739
APP PUB NO 20180003696A1
SERIAL NO

15542892

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Abstract

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Gene editing can be performed by introducing gene-editing components into a cell by mechanical cell disruption. Related apparatus, systems, techniques, and articles are also described. The methods and systems of the invention solve the problem of intracellular delivery of gene editing components and gene editing complexes to target cells. The results described herein indicate that delivery of gene editing components, e.g., protein, ribonucleic acid (RNA), and deoxyribonucleic acid (DNA), by mechanical disruption of cell membranes leads to successful gene editing. Because intracellular delivery of gene editing materials is a current challenge, the methods provide a robust mechanism to engineer target cells without the use of potentially harmful viral vectors or electric fields.

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Patent Owner(s)

Patent OwnerAddress
PRESIDENT AND FELLOWS OF HARVARD COLLEGE17 QUINCY STREET CAMBRIDGE MA 02138

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jensen, Klavs F Lexington, US 96 4016
Lajoie, Marc Seattle, US 11 26
Langer, Robert S Newton, US 623 35507
Sharei, Armon R Watertown, US 29 302

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