Compounds and methods for the modulation of proteins

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United States of America Patent

PATENT NO 10822369
APP PUB NO 20180009837A1
SERIAL NO

15525232

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Abstract

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In certain embodiments, the present disclosure provides compounds and methods of increasing the amount or activity of a target protein in a cell. In certain embodiments, the compounds comprise a translation suppression element inhibitor. In certain embodiments, the translation suppression element inhibitor is a uORF inhibitor. In certain embodiments, the uORF inhibitor is an antisense compound.

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Patent Owner(s)

  • IONIS PHARMACEUTICALS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Crooke, Stanley T Carlsbad, US 155 5482
Liang, Xue-hai Del Mar, US 20 22
Shen, Wen Carlsbad, US 19 167

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