CELLS FOR PRODUCING RECOMBINANT IDURONATE-2-SULFATASE
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United States of America Patent
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Jan 11, 2018
app pub date -
Jul 14, 2017
filing date -
Jun 29, 2012
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Abstract
The present invention provides, among other things, methods and compositions for production of recombinant I2S protein with improved potency and activity using cells co-express I2S and FGE protein. In some embodiments, cells according to the present invention are engineered to simultaneously over-express recombinant I2S and FGE proteins. Cells according to the invention are adaptable to various cell culture conditions. In some embodiments, cells of the present invention adaptable to a large-scale suspension serum-free culture.
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