for production of poly-R-3-hydroxyalkanoate polymers with defined monomer unit composition and methods based thereon

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United States of America Patent

PATENT NO 10745722
APP PUB NO 20180010156A1
SERIAL NO

15650265

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Abstract

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Methods and systems for producing prescribed unit size poly(3-hydroxyalkanoate) (PHA) polymers and copolymers are provided. The methods and systems can employ recombinant bacteria that are not native producers of PHA or lack enzymes to degrade PHA once synthesized, metabolize short to long chain fatty acids without induction, and express an (R)-specific enoyl-CoA hydratase and a PHA synthase, the (R)-specific enoyl-CoA hydratase and PHA synthase having wide substrate specificities. The recombinant bacteria are fed at least one fatty acid substrate that is equal in carbon length to the prescribed or desired unit size of the PHA polymer to be produced. The prescribed unit size PHA that is produced is then isolated and/or purified.

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Patent Owner(s)

Patent OwnerAddress
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK35 STATE STREET ALBANY NY 12207

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nomura, Christopher T Syracuse, US 8 22
Tappel, Ryan C Syracuse, US 2 12
Wang, Qin Syracuse, US 147 547

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