Methods for identifying, diagnosing, and predicting survival of lymphomas

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United States of America Patent

PATENT NO 10697975
APP PUB NO 20180011106A1
SERIAL NO

15630751

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Abstract

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Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.

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Patent Owner(s)

  • THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES; BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA; UNIVERSITY OF ROCHESTER; THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA; UNIVERSITAT DE BARCELONA; FUNDACIO CLINIC PER A LA RECERCA; HOSPITAL CLINIC DE BARCELONA; JULIUS-MAXIMILIANS-UNIVERSITY OF WÜRZBURG; BRITISH COLUMBIA CANCER AGENCY BRANCH; OSLO UNIVERSITY HOSPITAL HF; QUEEN MARY AND WESTFIELD COLLEGE UNIVERSITY OF LONDON

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Armitage, James Omaha, US 8 165
Bea, Silvia M Sabadell, ES 3 99
Campo, Guerri Elias Barcelona, ES 5 4
Chan, Wing C Pasadena, US 10 115
Connors, Joseph Vancouver, CA 3 99
Dave, Sandeep Chapel Hill, US 14 193
Delabie, Jan Toronto, CA 12 155
Fisher, Richard I Pittsford, US 6 102
Fu, Kai Omaha, US 34 139
Gascoyne, Randy North Vancouver, CA 5 101
Greiner, Timothy C Council Bluffs, US 5 106
Grogan, Thomas Tucson, US 12 176
Holte, Harald Oslo, NO 8 105
Jaffe, Elaine S Great Falls, US 8 11
Kvaloy, Stein Oslo, NO 5 97
Lister, T Andrew London, GB 3 99
Lopez-Guillermo, Armando Barcelona, ES 6 102
Miller, Thomas Tucson, US 168 3096
Montserrat, Emilio Barcelona, ES 1 1
Moreno, Victor Barcelona, ES 40 1044
Muller-Hermelink, Hans-Konrad Wurzburg, DE 7 104
Ott, German Bietigheim-Bissingen, DE 10 109
Powell, John I Ijamsville, US 3 99
Rimsza, Lisa M Scottsdale, US 6 1
Rosenwald, Andreas Wurzburg, DE 13 129
Salaverria, Itziar Barcelona, ES 3 99
Smeland, Erlend B Oslo, NO 8 11
Staudt, Louis M Bethesda, US 21 173
Tan, Bruce Chicago, US 4 113
Vose, Julie Omaha, US 3 99
Weisenburger, Dennis Glendora, US 10 109
Wilson, Wyndham Washington, US 8 138
Wright, George Rockville, US 24 934
Zettl, Andreas Wurzburg, DE 2 98

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