Spinosad heterologous expression strain and construction method thereof and use

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United States of America Patent

PATENT NO 10844415
APP PUB NO 20180016610A1
SERIAL NO

15526075

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Abstract

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The invention provides a construction method of spinosad heterologous expression strain, a spinosad heterologous expression strain obtained by the method and use thereof in preparing spinosad. The method utilizes a plurality of homologous recombination to replace the erythromycin synthetic gene cluster of Saccharopolyspora erythraea with the spinosad synthetic gene cluster and the rhamnose synthetic gene cluster, such that the Saccharopolyspora erythraea produces spinosad.

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Patent Owner(s)

Patent OwnerAddress
ZHEJIANG HISUN PHARMACEUTICAL CO LTDJIAOJIANG DISTRICT OF TAIZHOU CITY ZHEJIANG PROVINCE 318000 ROAD OUTSIDE NO 46 TAIZHOU CITY ZHEJIANG PROVINCE 318000

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bai, Hua Zhejiang, CN 113 414
Huang, Jun Zhejiang, CN 211 1910
Li, Meihong Zhejiang, CN 7 10
Li, Na Zhejiang, CN 361 1146
Wang, Haibin Zhejiang, CN 48 71
Yu, Zhen Zhejiang, CN 27 90
Zheng, Linghui Zhejiang, CN 7 5

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