Use of isocitrate dehydrogenase 1 as a diagnostic and prognostic biomarker and therapeutic target for lung cancers

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United States of America Patent

PATENT NO 10359426
APP PUB NO 20180017563A1
SERIAL NO

15719356

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Abstract

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The present invention relates to a method for diagnosing lung cancers such as non-small lung cancer in a subject by using isocitrate dehydrogenase 1 as a diagnostic biomarker. The present invention also relates to a method for predicting the prognosis of the lung cancers such as non-small lung cancer in a subject by using isocitrate dehydrogenase 1 as a prognostic biomarker. The present invention further relates to a method of suppressing proliferation of lung tumor cells in a subject, decreasing growth of lung tumor cells in a subject, or improving survival of a subject with lung cancer by using isocitrate dehydrogenase 1 as a therapeutic target.

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Patent Owner(s)

  • CANCER HOSPITAL, CHINESE ACADEMY OF MEDICAL SCIENCES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Zhaoli Beijing, CN 5 2
He, Jie Beijing, CN 131 526
Sun, Nan Beijing, CN 36 171
Tan, Fengwei Beijing, CN 2 1

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