PRODUCTION OF N-13 AMMONIA RADIONUCLIDE
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United States of America Patent
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Jan 18, 2018
app pub date -
Jul 12, 2017
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Jul 13, 2016
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Abstract
A method of producing 13N-ammonia for use in medical imaging is provided, which includes irradiating 14N (having a natural abundance of 99.64%) with a collimated bremsstrahlung radiation (gamma-ray beam) obtained by directing high-energy electrons onto a high-Z converter. The 14N to be irradiated may be in the form of liquid ammonia (14NH3) or ammonia gas to directly produce 13N-ammonia (13NH3) or in the form of liquid nitrogen to indirectly produce 13N-ammonia through conversion of the irradiated liquid nitrogen (N2) via known conversion processes to 13N-ammonia. The photons have an energy level above the threshold of the 14N(γ,n)13N reaction (about 10.5 MeV).
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