Adoptive T-cell therapy using EMPD-specific chimeric antigen receptors for treating IgE-mediated allergic diseases

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United States of America Patent

PATENT NO 11384156
APP PUB NO 20180022826A1
SERIAL NO

15651264

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A chimeric antigen receptor specific for the extracellular membrane-proximal domain (EMPD) of membrane-bound IgE (mIgE) is provided. The EMPD-specific chimeric antigen receptor comprises an extracellular ligand binding domain capable of binding EMPD, a transmembrane domain, and an intracellular domain that mediates T cell activation upon EMPD binding. Nucleic acids and vectors encoding the EMPD-specific chimeric antigen receptor are provided. T cells transduced with such vectors find use in chimeric antigen receptor-based adoptive T-cell therapy for targeting IgE-expressing B cells and treating IgE-mediated allergic diseases.

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Patent OwnerAddress
THE NEMOURS FOUNDATION4600 TOUCHTON ROAD EAST BLDG 200 SUITE 500 JACKSONVILLE FL 32246

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ma, Zhengyu Garnet Valley, US 6 6

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