Materials and methods for directing carbon flux and increased production of 7-aminoheptanoic acid or 6-aminohexanoic acid

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United States of America Patent

PATENT NO 11136603
APP PUB NO 20180023104A1
SERIAL NO

15656482

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Abstract

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This disclosure relates to genome-scale attenuation or knockout strategies for directing carbon flux to certain carbon based building blocks within the 7-aminoheptanoic acid (7-AHA) and 6-aminohexanoic acid (6-AHA) biosynthesis pathways, for example, to achieve reduced flux to unwanted side products while achieving increased production of desired intermediates and end products. This disclosure also relates to non-naturally occurring mutant bacterial strains comprising one or more gene disruptions in aldehyde reductase and/or aldehyde dehydrogenase genes that are generated to direct carbon flux to certain carbon based building blocks. This disclosure further relates to a method for enhancing production of carbon based building blocks by generating non-naturally occurring mutant bacterial strains, culturing said mutant bacterial strains in the presence of suitable substrates or under desired growth conditions, and substantially purifying the desired end product.

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Patent Owner(s)

  • INV NYLON CHEMICALS AMERICAS, LLC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cartman, Stephen Stockton-on-Tees, GB 1 7
Combe, Jonathan North Yorkshire, GB 2 9
Foster, Alexander B Yarm, GB 1 7
Kennedy, Jonathan North Yorkshire, GB 62 232

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