Nanoemulsion compositions of taxoid drugs, and methods for the use thereof to target cancer cells and cancer stem cells

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 10206875
APP PUB NO 20180028442A1
SERIAL NO

15616103

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Abstract

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A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.

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Patent Owner(s)

  • TARGAGENIX, INC.; THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY NEW YORK; NORTHEASTERN UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Amiji, Mansoor M Attleboro, US 22 967
Botchkina, Galina Ivanovna Stony Brook, US 1 1
Egan, James E Massapequa Park, US 12 80
Ojima, Iwao Port Jefferson, US 54 411

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