PERTUZUMAB VARIANTS AND EVALUATION THEREOF

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United States of America Patent

SERIAL NO

15788632

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Abstract

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The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof.

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Patent Owner(s)

Patent OwnerAddress
GENENTECH INCCALIFORNIA USA CALIFORNIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gennaro, Lynn A San Mateo, US 8 44
Kao, Yung-Hsiang San Mateo, US 22 409
Zhang, Yonghua Foster City, US 18 73

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