Perivascular drug delivery system

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United States of America Patent

PATENT NO 10668017
APP PUB NO 20180042844A1
SERIAL NO

15674293

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Abstract

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The present technology provide compositions that are drug delivery systems for the sustained release of anti-stenotic drugs for the treatment and prevention of occlusion of blood vessels, particularly after perivascular surgery. The compositions include a hydrogel, unimolecular micelles dispersed within the hydrogel, and an effective amount of anti-stenotic drug dispersed within the unimolecular micelle. The hydrogel may be a di-or tri-block copolymer comprising one block of poly(ethylene glycol) (PEG) and one or two blocks of poly(lactic-co-glycolic acid) (PLGA). The unimolecular micelle may include three domains: a dendritic polymer core, hydrophobic block polymers (e.g., PVL, PVCL, and/or PCL) attached to the core and PEG attached to the hydrophobic block polymers.

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Patent Owner(s)

Patent OwnerAddress
WISCONSIN ALUMNI RESEARCH FOUNDATION614 WALNUT STREET MADISON WI 53726

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Guojun Madison, US 32 73
Gong, Shaoqin Middleton, US 101 356
Guo, Lian-Wang Madison, US 3 1
Kent, K Craig Fitchburg, US 6 1
Shi, Xudong Madison, US 29 108

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