MICROSOMAL BIOREACTOR FOR SYNTHESIS OF DRUG METABOLITES

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United States of America Patent

SERIAL NO

15552068

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Abstract

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Reusable microsomal biocatalytic systems (bioreactors) constructed on carbon nanostructure modified electrodes are provided. The bioreactors comprise stable, biologically active immobilized enzymes such as human cytochromes P 450 (CYPs) and their redox partner proteins, e.g. CYP-NADPH (reduced nicotinamide adenine dinucleotide phosphate) reductases (CPR), on the carbon nanostructure surface. The immobilized enzymes may be present in liver microsomes, such as human liver microsomes (HLM) or as bactosomes, S9 fractions, etc. The bioreactors are used, for example, for synthesizing metabolites of interest from compounds such as drugs that are catabolized by the enzymes.

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THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY1201 S INNOVATION WAY DR SUITE 210 STILLWATER OK 74074

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
KRISHNAN, Sadagopan Stillwater, US 2 0
NERIMETLA, Rajasekhara Reddy Stillwater, US 2 0
WALGAMA, Charuksha Thameera Stillwater, US 2 0

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