METHODS FOR DETECTING ADVERSE LOCAL TISSUE REACTION (ALTR) NECROSIS

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United States of America Patent

APP PUB NO 20180045737A1
SERIAL NO

15664402

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Abstract

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This invention relates to field of screening and diagnosing adverse local tissue reaction (ALTR) in a subject who has received a joint replacement by measuring the level of a nucleic acid or protein biomarker that are elevated in patients suffering from ALTR, even those with no symptoms. The early diagnosis of the ALTR can lead to its treatment and thus, the prevention of implant failure caused by the ALTR. The elevated proteins and genes are also the basis for treatment for ALTR and provide targets for drug development and basic research.

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Patent Owner(s)

Patent OwnerAddress
CD DIAGNOSTICS INC650 NAAMANS RD #100 CLAYMONT DE 19703

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Deirmengian, Carl Newton Square, US 27 215
Fehring, Thomas K Charlotte, US 7 630
Joaquim, Tony Mount Laurel, US 5 0
Kardos, Keith Bethlehem, US 18 164
Stave, James W Bear, US 14 229

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