Method and apparatus for tiling light sheet selective plane illumination microscopy with real-time optimized light sheet

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United States of America Patent

PATENT NO 10222600
APP PUB NO 20180045941A1
SERIAL NO

15552893

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Disclosed are a method and apparatus for tiling light sheet selective plane illumination microscopy (TLS-SPIM) with real-time light sheet optimization. The method and apparatus image multi-cellular specimens in 3D, with an improved 3D imaging ability of SPIM in resolving complex structures and optimizes SPIM live imaging performance by using a real-time adjustable tiling light sheet and creating a flexible compromise between spatial and temporal resolution. A 3D live imaging ability is provided of the TLS-SPIM by real-time imaging cellular and sub-cellular behaviors.

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Patent Owner(s)

  • THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gao, Liang Rockville, US 115 538

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