Toll-like receptor 2 ligands and methods of making and using thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 10118942
APP PUB NO 20180051055A1
SERIAL NO

15561230

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers, and as an adjuvant for cancer immunotherapy. The monoacylated compounds disclosed herein have a higher binding affinity for TLR2 relative to a known potent diacylated agonists, but only −½ the bioactivity. Competition of the monoacylated compound with the diacylated compound for binding TLR2 was confirmed. Hence, the reported monoacylated compounds are inhibitors/antagonists of TLR2 activation.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

  • H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC.; THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA; UNIVERSITY OF SOUTH FLORIDA

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Doligalski, Michael Lutz, US 3 4
Gillies, Robert Tampa, US 12 132
Huynh, Amanda Land O Lakes, US 5 18
McLaughlin, Mark Tampa, US 51 608
Morse, David L Tampa, US 44 729
Vagner, Josef Tucson, US 23 108

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
7.5 Year Payment $3600.00 $1800.00 $900.00 May 6, 2026
11.5 Year Payment $7400.00 $3700.00 $1850.00 May 6, 2030
Fee Large entity fee small entity fee micro entity fee
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00