Bi-specific antibodies against Tim-3 and PD-1 for immunotherapy in chronic immune conditions

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United States of America Patent

PATENT NO 10934352
APP PUB NO 20180051083A1
SERIAL NO

15803079

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Described herein are novel compositions comprising bispecific and multispecific polypeptide agents, and methods using these agents for targeting cells, such as functionally exhausted or unresponsive immune cells, that co-express the inhibitory receptors PD-1 and TIM-3. These compositions and methods are useful for the treatment of chronic immune conditions, such as persistent infections or cancer.

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Patent Owner(s)

Patent OwnerAddress
THE BRIGHAM AND WOMEN'S HOSPITAL INC75 FRANCIS STREET BOSTON MA 02115

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Anderson, Ana C Newton, US 13 183
Kuchroo, Vijay K Newton, US 63 556

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