ARRDC1-mediated microvesicles (ARMMS) and uses thereof

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United States of America Patent

PATENT NO 10945954
APP PUB NO 20180055768A1
SERIAL NO

15669720

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Abstract

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The invention provide isolated arrestin domain-containing protein 1 (ARRDC1)-mediated microvesicles (ARMMs). Methods for generating and for isolating ARMMs are also provided herein. ARMMs can be used to deliver agents, for example, nucleic acids (e.g., siRNAs, microRNAs, lincRNAs), proteins (e.g., transcription factors, chromatin modulators, kinases, phosphorylases, or recombinases), or small molecules to target cells in vitro and in vivo, and methods for such ARMM-mediated delivery are provided herein. Diagnostic and therapeutic methods using ARMMs are also described herein.

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Patent Owner(s)

  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cohen, Stanley N Palo Alto, US 50 975
Lu, Quan Newton, US 31 559
Nabhan, Joseph F Cambridge, US 4 19

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