Universal antibody-mediated biosensor

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United States of America Patent

PATENT NO 11440946
APP PUB NO 20180057562A1
SERIAL NO

15557603

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Abstract

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A universal antibody-mediated biosensor is provided that comprise a biosensor cell line stably expressing a novel chimeric fusion protein that can be used to detect target agents in a sample. The fusion protein has an extracellular antibody-binding domain that binds antibodies without regard to their binding specificity and a signaling domain that induces cellular activation upon antigen binding. Because the fusion protein binds to the Fc region of any antibody, it can serve as a universal pathway between extracellular signaling and intracellular activation. The biosensor can be used to detect the presence of selected antigens in a sample.

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Patent Owner(s)

  • THE UNIVERSITY OF MARYLAND BALTIMORE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Schulze, Dan Towson, US 1 0
Strome, Scott E Reisterstown, US 40 877

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