Multispecific Antibodies Facilitating Selective Light Chain Pairing

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United States of America Patent

APP PUB NO 20180057567A1
SERIAL NO

15687055

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Abstract

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Provided herein are multispecific antibodies, e.g. bispecific antibodies, which are modified such that the desired chain pairing takes place and/or can be selected for. Specifically, this is achieved by using different dimerization domains for light chain pairing. Also disclosed herein are nucleic acids encoding for these antibodies, expression vectors comprising these nucleic acids, cells expressing them, and further to pharmaceutical compositions comprising the antibodies, as well as methods of isolating the antibodies.

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SANOFI54 RUE LA BOETIE PARIS 75008

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beil, Christian Frankfurt am Main, DE 15 62
Focken, Ingo Frankfurt am Main, DE 9 20
Kroll, Katja Frankfurt am Main, DE 6 3
Lange, Christian Frankfurt am Main, DE 50 152
Langer, Thomas Frankfurt am Main, DE 36 311
Leuschner, Wulf-Dirk Frankfurt am Main, DE 3 0
Rao, Ercole Frankfurt am Main, DE 40 161
Spindler, Nadja Frankfurt am Main, DE 2 5

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