MULTIVALENT AND MULTIEPITOPIC ANTIBODIES HAVING AGONISTIC ACTIVITY AND METHODS OF USE

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United States of America Patent

SERIAL NO

15669861

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Abstract

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Provided herein are tetravalent antigen binding complexes having agonist activity for a cell surface receptor. In some embodiments, the complexes comprise binding specificities for multiple epitopes of the same cell surface receptor. Further provided herein are nucleic acids, vectors, host cells, pharmaceutical compositions, and methods of production related thereto.

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Patent Owner(s)

Patent OwnerAddress
F HOFFMANN-LA ROCHE AGBASEL SUI BASEL BASEL-STADT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CHRISTENSEN, Erin H Tiburon, US 5 62
HANG, Julie South San Francisco, US 2 8
HARRIS, Seth South San Francisco, US 11 68
KIM, Jeong San Francisco, US 39 338
LAZAR, Greg South San Francisco, US 8 39
YANG, Yanli South San Francisco, US 9 22

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