T cells

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United States of America Patent

PATENT NO 10801011
APP PUB NO 20180057793A1
SERIAL NO

15691179

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Provided is a method for isolating and proliferating autologous cancer antigen-specific CD8+T cells, and more particularly, a method for selecting an epitope recognized by CD8+ T cells from autologous cancer antigens present in blood of individual cancer patients; and isolating autologous cancer antigen-specific CD8+ T cells by using a peptide of the selected epitope, and a method of massively proliferating CD8+ T cells by using the method. According to the present invention, it is possible to isolate autologous cancer antigen-specific CD8+ T cells by using the peptide of the CD8 T cell epitope of the autologous cancer antigen present in blood of individual cancer patients instead of a heterologous antigen. Therefore, by using T cells recognizing the autologous cancer antigen, it is possible to effectively select and eliminate cancer cells derived from the cancer patient's own cells. Thus, T cells can be applied to treatment and alleviation of cancer diseases without side effects.

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Patent Owner(s)

Patent OwnerAddress
NATIONAL CANCER CENTER323 ILSAN-RO ILSANDONG-GU GOYANG-SI GYEONGGI-DO 10408

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Choi, Beom-Kyu Gyeonggi-do, KR 6 35
Eom, Hyeon-Seok Seoul, KR 3 11
Kang, Hyun-Guy Seoul, KR 4 27
Kim, Kwang-Hui Gyeonggi-do, KR 7 35
Kim, Young-Ho Gyeonggi-do, KR 254 2662
Kim, Young-Woo Gyeonggi-do, KR 41 981
Kwon, Byoung S Gwangmyeong-si, KR 44 373
Lee, Don-Gil Gyeonggi-do, KR 8 36
Lee, Jin-Soo Gyeonggi-do, KR 87 482
Lee, Seung-Hoon Seoul, KR 234 3553
Lee, Young-Joo Seoul, KR 34 179
Oh, Ho-Sik Goyang-si, KR 10 54
Park, Byung-Kiu Seoul, KR 3 11
Park, Sang-Jae Gyeonggi-do, KR 17 463
Park, Sang-Yoon Seoul, KR 9 18
Yoo, Heon Seoul, KR 10 34

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