Functional screening with optimized functional CRISPR-Cas systems

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United States of America Patent

PATENT NO 11001829
APP PUB NO 20180057810A1
SERIAL NO

15469081

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Abstract

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The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.

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Patent Owner(s)

  • THE BROAD INSTITUTE, INC.; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; PRESIDENT AND FELLOWS OF HARVARD COLLEGE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brigham, Mark D Cambridge, US 4 228
Konermann, Silvana Cambridge, US 39 666
Trevino, Alexandra Cambridge, US 1 5
Zhang, Feng Cambridge, US 900 23387

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