rAAV vector compositions, methods for targeting vascular endothelial cells and use in treatment of type I diabetes

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 10648000
APP PUB NO 20180057840A1
SERIAL NO

15550864

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Abstract

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Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations that include them. Also disclosed are methods of preparing and using novel capsid-protein-mutated rAAV vector constructs in a variety of diagnostic and therapeutic applications including, inter alia, as delivery agents for diagnosis, treatment, or amelioration of one or more diseases, disorders, or dysfunctions of the mammalian vascular system, and complications from Type I diabetes. Also disclosed are methods for systemic and tissue-localized delivery of therapeutic rAAV-based gene expression cassettes to vascular endothelial cells, tissues, and organs, as well as use of the disclosed compositions in the manufacture of medicaments for a variety of in vitro and/or in vivo applications including the treatment of vasculitis, and complications arising from Type I diabetes, such as macular edema, nephropathy, diabetic retinopathy, and the like.

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Patent Owner(s)

  • UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boulton, Michael E Chelsea, US 1 6
Boye, Sanford L Gainesville, US 24 103
Boye, Shannon E Gainesville, US 17 86
Hauswirth, William W Gainesville, US 44 652
Lipinski, Daniel M Milwaukee, US 3 6

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