Method of increasing the function of an AAV vector

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United States of America Patent

PATENT NO 10626415
SERIAL NO

15796115

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Abstract

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A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.

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Patent Owner(s)

  • THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gao, Guangping Westborough, US 186 6069
Vandenberghe, Luk Weston, US 15 208
Wilson, James M Philadelphia, US 387 10498

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