Vectors and methods for targeted integration in loci comprising constitutively expressed genes

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United States of America Patent

PATENT NO 10745717
APP PUB NO 20180057842A1
SERIAL NO

15525380

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Abstract

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The invention relates to a vector comprising: a 5′ nucleic acid that is homologous to a genomic sequence 5′ of a stop codon of a constitutively expressed gene; an exogenous nucleic acid; a 3′ nucleic acid that is homologous to a genomic sequence 3′ of the stop codon of the constitutively expressed gene; a translation interruption-reinitiation signal operably linked to the 5′ nucleic acid and the exogenous nucleic acid, wherein the translation interruption-reinitiation signal is capable of replacing the stop codon of the constitutively expressed gene.

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Patent Owner(s)

Patent OwnerAddress
BLUEROCK THERAPEUTICS LP238 MAIN STREET 3RD FLOOR CAMBRIDGE MA 02142

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Elefanty, Andrew Victoria, AU 4 4
Elliott, David Victoria, AU 22 109
Labonne, Tatiana Victoria, AU 1 0
Stanley, Ed Victoria, AU 1 0

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